Phenotypes Associated with This Genotype

Genotype
MGI:5432239

• Allelic Composition: Apc^tm2Rak/Apc^tm2Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased carcinoma incidence ( J:156532 )

• 7% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are carcinomas

increased organ/body region tumor incidence ( J:156532 )

• 71% of mutants injected with an adenovirus expressing cre recombinase in the distal colon to inactivate Apc develop distal colonic tumors as little as 6 weeks after viral administration

• rapamycin treatment of mutants with tumors results in tumor regression, with mice showing an 82% reduction in tumor size

increased colon adenoma incidence ( J:156532 )

• 93% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas

digestive/alimentary system

increased colon adenoma incidence ( J:156532 )

• 93% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:156532