Phenotypes Associated with This Genotype

Genotype
MGI:5432240

• Allelic Composition: Apc^tm2Rak/Apc^tm2Rak; Kras^tm4Tyj/Kras⁺
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased carcinoma incidence ( J:156532 )

• 36% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are carcinomas

increased adenocarcinoma incidence ( J:156532 )

• 20% of mutants injected with an adenovirus expressing cre recombinase in the distal colon to inactivate Apc exhibit spontaneous gross liver metastases starting 24 weeks after adenoviral injection; these lesions are adenocarcinomas

increased organ/body region tumor incidence ( J:156532 )

• 96% of mutants injected with an adenovirus expressing cre recombinase in the distal colon to inactivate Apc develop distal colonic tumors as little as 3 weeks after viral administration

• rapamycin treatment of mutants with tumors does not result in tumor regression

increased colon adenoma incidence ( J:156532 )

• 64% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas

digestive/alimentary system

increased colon adenoma incidence ( J:156532 )

• 64% of tumors that develop in mutant colons injected with an adenovirus expressing cre recombinase are adenomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:156532