Phenotypes Associated with This Genotype

Genotype
MGI:5432344

• Allelic Composition: Tg(Ela1-Myc)158Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:76992 )

• mutants die between 2 and 7 months of age

neoplasm

increased pancreas tumor incidence ( J:76992 )

• mutants develop pancreatic tumors; tumor progression begins with a thickening of the pancreas at 1 month of age, the then development of 1-10 firm pale small pancreatic nodules at 1-4 months of age, and excessive tumor burden leading to death begins at 2 months of age

• during tumor development, acinar-like cells eventually replace islet tissue and eventually neoplastic ductal elements arise within acinar cell tumors to progress into mixed or ductal adenocarcinomas

• about 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

• focal areas of some tumors exhibit squamous metaplasia or adenosquamous carcinoma

• tumors are frequently associated with inflammatory cell infiltrate

increased pancreatic acinar cell carcinoma incidence ( J:76992 )

• about 50% of tumors exhibit characteristics of acinar cell carcinomas, the remaining 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

increased metastatic potential ( J:76992 )

• 1 of 10 mutants exhibit tumors that spread to peritoneal surfaces or the liver

liver/biliary system

jaundice ( J:76992 )

• some mutants are jaundiced

endocrine/exocrine glands

exocrine pancreas atrophy ( J:76992 )

• non-tumor portions of the pancreas appear atrophied

small pancreas ( J:76992 )

• small pancreas in some mutants

increased pancreas tumor incidence ( J:76992 )

• mutants develop pancreatic tumors; tumor progression begins with a thickening of the pancreas at 1 month of age, the then development of 1-10 firm pale small pancreatic nodules at 1-4 months of age, and excessive tumor burden leading to death begins at 2 months of age

• during tumor development, acinar-like cells eventually replace islet tissue and eventually neoplastic ductal elements arise within acinar cell tumors to progress into mixed or ductal adenocarcinomas

• about 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

• focal areas of some tumors exhibit squamous metaplasia or adenosquamous carcinoma

• tumors are frequently associated with inflammatory cell infiltrate

increased pancreatic acinar cell carcinoma incidence ( J:76992 )

• about 50% of tumors exhibit characteristics of acinar cell carcinomas, the remaining 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

digestive/alimentary system

exocrine pancreas atrophy ( J:76992 )

• non-tumor portions of the pancreas appear atrophied

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:76992