Phenotypes Associated with This Genotype

Genotype
MGI:5432910

• Allelic Composition: Mas1^tm1Bdr/Mas1^tm1Bdr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:162698 )

N • at 9-10 weeks of age, kidney weight, cortical tubule diameter, and Bowman's space diameter remain normal

decreased renal plasma flow rate ( J:162698 )

• renal blood flow is significantly reduced

increased renal vascular resistance ( J:162698 )

• total renal vascular resistance is significantly increased

decreased urine sodium level ( J:162698 )

• fractional excretion of sodium is significantly reduced

increased urine osmolality ( J:162698 )

• urinary osmolality is significantly increased

albuminuria ( J:162698 )

• urinary albumin excretion is significantly elevated

increased urine microalbumin level ( J:162698 )

• 6.7-fold increase

abnormal renal glomerular capsule morphology ( J:162698 )

• Bowman's capsule diameter is significantly reduced

• however, Bowman's space diameter remains normal

abnormal renal glomerulus morphology ( J:162698 )

• glomerulus tuft diameter is significantly reduced

• however, no glomerular hypertrophy is observed

renal glomerulus fibrosis ( J:162698 )

• increased expression of collagen IV and fibronectin in the mesangium

• however, normal expression of collagen types I and III in the mesangium

renal interstitial fibrosis ( J:162698 )

• increased expression of collagen III, collagen IV, and fibronectin in the renal interstitium (cortex and medulla)

• however, normal expression of collagen I in both cortex and medulla

increased creatinine clearance ( J:162698 )

• creatinine clearance is significantly increased

increased renal glomerular filtration rate ( J:162698 )

• GFR is significantly elevated (1.8-fold), as measured by creatinine and inulin clearances

decreased urine flow rate ( J:162698 )

• 24-h urine flow is significantly reduced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:162698 )

N • Background Sensitivity: no differences in blood glucose levels are observed on a C57BL/6 background

N • plasma osmolality, osmolal, and free-water clearance are normal

N • fractional excretion of potassium is normal

decreased urine sodium level ( J:162698 )

• fractional excretion of sodium is significantly reduced

increased urine osmolality ( J:162698 )

• urinary osmolality is significantly increased

albuminuria ( J:162698 )

• urinary albumin excretion is significantly elevated

increased urine microalbumin level ( J:162698 )

• 6.7-fold increase

cardiovascular system

cardiovascular system phenotype ( J:162698 )

N • Background Sensitivity: mean arterial pressure is normal on a C57BL/6 background

decreased renal plasma flow rate ( J:162698 )

• renal blood flow is significantly reduced

increased renal vascular resistance ( J:162698 )

• total renal vascular resistance is significantly increased

behavior/neurological

behavior/neurological phenotype ( J:162698 )

N • no differences in water and food intake are observed