Phenotypes Associated with This Genotype

Genotype
MGI:5433031

• Allelic Composition: Gabra1^tm1.1Geh/Gabra1⁺
• Genetic Background: D2.129(Cg)-Gabra1^tm1.1Geh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absence seizures ( J:186685 )

• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges

abnormal spike wave discharge ( J:186685 )

• Background Sensitivity: heterozygotes on a DBA/2J congenic background display an average of 19 spike wave discharge events per hour with no significant difference found between genders

nervous system

absence seizures ( J:186685 )

• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges

abnormal spike wave discharge ( J:186685 )

• Background Sensitivity: heterozygotes on a DBA/2J congenic background display an average of 19 spike wave discharge events per hour with no significant difference found between genders

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
idiopathic generalized epilepsy		DOID:1827	OMIM:600669	J:186685