Phenotypes Associated with This Genotype

Genotype
MGI:5433072

• Allelic Composition: Tff1^tm1Mrio/Tff1^tm1Mrio
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased stomach tumor incidence ( J:84201 )

• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach

• mutants develop gastric tumors

digestive/alimentary system

abnormal stomach mucosa morphology ( J:84201 )

• mutants exhibit dysplastic lesions in the antral mucosa; dysplastic glands are lined by epithelial cells that, in contrast to controls, are crowded and overlapping, and whose nuclei show hyperchromasia, irregular nuclear contours, and pleomorphism

increased stomach mucosa thickness ( J:84201 )

• antral mucosa is thickened, with disorganized, complex architecture

increased stomach tumor incidence ( J:84201 )

• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach

• mutants develop gastric tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:84201