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Phenotypes Associated with This Genotype
Genotype
MGI:5433725
Allelic
Composition
Pklrslc/Pklrslc
Genetic
Background
CBA/NSlc-Pklrslc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pklrslc mutation (0 available); any Pklr mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice infected with malaria parasite P. chabaudi

hematopoietic system
• 4.6 times in male mice
• 6.4 times in female mice
• increased CFU-S cells in the spleen
• in the red pulp (J:30035)
• increased (J:141722)
• more severe than in Pklrchar4 homozygotes
• chronic (J:29199)
• severe nonspherocytic anemia (J:30035)
• however, anemia is rescued by bone marrow transplant with wild-type bone marrow (J:30035)
• 2.3 times in the bone marrow
• 66 times in the spleen

homeostasis/metabolism
• in the red pulp
• mice exhibit an almost complete loss of pyruvate kinase activity

immune system
• 4.6 times in male mice
• 6.4 times in female mice
• mice infected with the malaria parasite Plasmodium chabaudi AS exhibit lower parasitemia and no mortality unlike control mice
• in mice infected with malaria parasite P. chabaudi

growth/size/body
• 4.6 times in male mice
• 6.4 times in female mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pyruvate kinase deficiency of red cells DOID:0111077 OMIM:266200
J:29199


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory