mortality/aging
• in Salmonella typhimurium-infected mice
|
• in mice infected with malaria parasite P. chabaudi
|
hematopoietic system
• 4.6 times in male mice
• 6.4 times in female mice
|
• increased CFU-S cells in the spleen
|
• in the red pulp
(J:30035)
• increased
(J:141722)
|
• chronic
(J:29199)
• severe nonspherocytic anemia
(J:30035)
• however, anemia is rescued by bone marrow transplant with wild-type bone marrow
(J:30035)
|
• 2.3 times in the bone marrow
• 66 times in the spleen
|
homeostasis/metabolism
hemosiderosis
(
J:30035
)
• in the red pulp
|
• mice exhibit an almost complete loss of pyruvate kinase activity
|
immune system
• 4.6 times in male mice
• 6.4 times in female mice
|
• in Salmonella typhimurium-infected mice
|
• mice infected with the malaria parasite Plasmodium chabaudi AS exhibit lower parasitemia and no mortality unlike control mice
|
• in mice infected with malaria parasite P. chabaudi
|
growth/size/body
• 4.6 times in male mice
• 6.4 times in female mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
pyruvate kinase deficiency of red cells | DOID:0111077 |
OMIM:266200 |
J:29199 |