Phenotypes Associated with This Genotype

Genotype
MGI:5435319

• Allelic Composition: Lepr^db/Lepr⁺; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

amyloidosis ( J:186924 )

• mutants exhibit an increase in expression of amyloid beta protein in plasma compared to Lepr^db heterozygotes, however they do not show amyloid beta plaques yet at 5-7 weeks of age

increased circulating glucose level ( J:186924 )

• nonfasting blood glucose levels are elevated compared to control Lepr^db heterozygotes

• however, fasting blood glucose is normal at 5-7 weeks of age

increased circulating insulin level ( J:186924 )

• nonfasting and fasting hyperinsulinemia

abnormal circulating cholesterol level ( J:186924 )

• elevation in nonfasting plasma cholesterol levels

• however, fasting cholesterol levels are normal

impaired glucose tolerance ( J:186924 )

insulin resistance ( J:186924 )

• mutants exhibit decreased insulin sensitivity

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:186924 )

• increase in beta cell mass and beta cell area compared to control Lepr^db heterozygotes

growth/size/body

growth/size/body region phenotype ( J:186924 )

N • body weight is normal at 5-7 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:186924
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:186924