Phenotypes Associated with This Genotype

Genotype
MGI:5435567

• Allelic Composition: Porcn^tm1.1Vdv/Y; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal abnormalities in Porcn^tm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0 mice

growth/size/body

decreased body size ( J:186934 )

♂ • at P7

postnatal growth retardation ( J:186934 )

♂ • become progressively stunted between P7 and P28

limbs/digits/tail

brachydactyly ( J:186934 )

♂

syndactyly ( J:186934 )

♂ • soft tissue syndactyly in some mice on both the fore- and hindlimbs

short limbs ( J:186934 )

♂

skeleton

decreased length of long bones ( J:186934 )

♂ • long bones of all extremities and digits are short

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:186934