Phenotypes Associated with This Genotype

Genotype
MGI:5435676

• Allelic Composition: Fktn^tm1Kcam/Fktn^tm1Kcam; Myf5^tm3(cre)Sor/Myf5⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187144 )

• 11% die before 20 weeks of age even with special feeding

• remainder are dead or euthanized by 35 weeks

growth/size/body

decreased body weight ( J:187144 )

• significantly under weight

• combined gastrocnemius and soleus weight is low

muscle

dystrophic muscle ( J:187144 )

• moderate to severe dystrophic features in the iliopsoas muscle at 20 weeks

homeostasis/metabolism

increased circulating creatine kinase level ( J:187144 )

• elevated at 4 and 8 weeks

behavior/neurological

decreased grip strength ( J:187144 )

• forelimb grip strength is reduced

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fukuyama congenital muscular dystrophy		DOID:0050559	OMIM:253800	J:187144