Phenotypes Associated with This Genotype

Genotype
MGI:5436309

• Allelic Composition: Pink1^tm1.1Wrst/Pink1^tm1.1Wrst
• Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:183290 )

N • no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected

N • no decrease in striatal dopamine content is detected at 6 months of age

abnormal olfactory bulb glomerular layer morphology ( J:183290 )

• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

abnormal innervation ( J:183290 )

• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological

behavior/neurological phenotype ( J:183290 )

N • locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls

abnormal gait ( J:183290 )

♂ • decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age

♂ • maximum contact is increased in the hindpaws in males at 26 months of age

♂ • marked change in interpaw coordination

abnormal sensory capabilities/reflexes/nociception ( J:183290 )

• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

abnormal social investigation ( J:183290 )

• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular

abnormal mitochondrial morphology ( J:183290 )

• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction

abnormal olfaction ( J:183290 )

♂ • aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 6		DOID:0060369	OMIM:605909	J:183290