Phenotypes Associated with This Genotype

Genotype
MGI:5437114

• Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo
• Genetic Background: C57BL/6J-Dnah11^b2b1289Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1289-003-NA shows levocardia, right aortic arch and ambiguous lung lobation

cardiovascular system

isolation of the left subclavian artery ( J:175213 )

right aortic arch ( J:175213 )

vascular ring ( J:175213 )

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

muscular ventricular septal defect ( J:175213 )

growth/size/body

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

polycystic kidney ( J:175213 )

heterotaxia ( J:175213 )

abdominal situs ambiguus ( J:175213 )

left-sided isomerism ( J:175213 )

left pulmonary isomerism ( J:175213 )

situs inversus with levocardia ( J:175213 )

hematopoietic system

accessory spleen ( J:175213 )

immune system

accessory spleen ( J:175213 )

liver/biliary system

abnormal liver morphology ( J:175213 )

• midline liver

renal/urinary system

polycystic kidney ( J:175213 )

hydronephrosis ( J:175213 )

duplex kidney ( J:175213 )

respiratory system

left pulmonary isomerism ( J:175213 )

vision/eye

microphthalmia ( J:175213 )

anophthalmia ( J:175213 )

muscle

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 7		DOID:0110605	OMIM:611884	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213