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Phenotypes Associated with This Genotype
Genotype
MGI:5437125
hm1
Allelic
Composition
Acot13tm1Deco/Acot13tm1Deco
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acot13tm1Deco mutation (0 available); any Acot13 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice fed a high fat diet fail to exhibit an increase in circulating ketone body levels (beta-hydroxybutyrate) unlike wild-type mice
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• mice fed a high fat diet exhibit increased glucose clearance compared with wild-type mice
• mice fed a high fat diet exhibit reduced hepatic glucose production compared with wild-type mice
• in mice fed a high fat diet
• mice fed standard chow exhibit reduced intestinal lipid absorption compared with wild-type mice
• mice fed standard chow exhibit increased feces lipid composition compared with wild-type mice
• however, mice fed a high-fat diet exhibit normal lipid absorption
• mice fed standard chow exhibit increased feces lipid composition, including triglycerides, compared with wild-type mice
• mice fed a high fat diet fail to exhibit an increase in circulating free fatty acids unlike wild-type mice
• in mice fed a high fat diet
• in mice fed a high fat diet
• mice fed a high-fat diet exhibit decreased heat production compared with wild-type mice
• mice exhibit reduced mitochondrial fatty acyl-CoA thioesterase activity in the liver compared with wild-type mice

adipose tissue
• in mice fed standard chow or a high fat diet
• in mice fed standard chow or a high fat diet

growth/size/body
• in mice fed standard chow or a high fat diet
• modest in mice fed standard chow or a high fat diet

behavior/neurological
• in mice fed standard chow or a high fat diet
• during the light phase in mice fed standard chow

digestive/alimentary system
• mice fed standard chow exhibit increased feces lipid composition, including triglycerides, compared with wild-type mice

liver/biliary system
• in mice fed a high fat diet
• in mice fed a high fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory