Phenotypes Associated with This Genotype

Genotype
MGI:5437224

• Allelic Composition: Sox7^tm1.1Dsco/Sox7⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal diaphragm morphology ( J:187416 )

• in some cases the gallbladder is fused to the underside of the anterior diaphragm

diaphragmatic hernia ( J:187416 )

• Background Sensitivity: around 14% of mice (10 of 71, age P28 to adult) on a mixed 129 and C57BL/6 background have congenital diaphragmatic hernia located directly behind the sternum in the ventral midline; hernias are not seen in mice on a congenic C57BL/6 background

• in severe cases the gallbladder and a pedunculated portion of the liver are found in the thoracic cavity

liver/biliary system

abnormal gallbladder morphology ( J:187416 )

• in some cases the gallbladder is fused to the underside of the anterior diaphragm

endocrine/exocrine glands

abnormal gallbladder morphology ( J:187416 )

• in some cases the gallbladder is fused to the underside of the anterior diaphragm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital diaphragmatic hernia		DOID:3827	OMIM:142340 OMIM:222400 OMIM:610187	J:187416