Phenotypes Associated with This Genotype

Genotype
MGI:5437484

• Allelic Composition: Tg(Alb-E2F1)8Sst/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased liver tumor incidence ( J:65354 , J:101128 )

• liver tumor progression begins with preneoplastic foci adjacent to portal tracts and pericentral large cell dysplasia at 2 months of age, followed by an abrupt increase in the number of neoplastic nodules or adenomas from 4-6 months onward, with 100% incidence by 10 months of age, and finally some adenomas show evidence of malignant transformation into trabecular hepatocellular carcinoma (J:65354)

increased hepatocellular carcinoma incidence ( J:65354 , J:101128 )

• mice show features of malignant transformation in some of the adenomas by 10 months of age (J:65354)

• 60% of mutants develop hepatocellular carcinoma by 12 months of age (J:101128)

• tumors are predominantly well-differentiated (J:101128)

increased liver adenoma incidence ( J:65354 )

• 100% incidence of adenomas by 10-12 months of age

liver/biliary system

increased hepatocyte proliferation ( J:65354 )

• livers show an increase in cell proliferation; at one month of age, the proliferation index is increased about 1.4-fold compared to wild-type, then proliferation decreases at 2 months of age so it is 2-fold lower than at 1 months of age but it is 6-fold higher than in wild-type livers at this time

macrovesicular hepatic steatosis ( J:65354 )

• macrovesicular hepatic steatosis is first seen in livers at 6-8 months of age and by 10-12 months of age, 60% of mutants develop prominent fatty change

increased liver tumor incidence ( J:65354 , J:101128 )

• liver tumor progression begins with preneoplastic foci adjacent to portal tracts and pericentral large cell dysplasia at 2 months of age, followed by an abrupt increase in the number of neoplastic nodules or adenomas from 4-6 months onward, with 100% incidence by 10 months of age, and finally some adenomas show evidence of malignant transformation into trabecular hepatocellular carcinoma (J:65354)

increased hepatocellular carcinoma incidence ( J:65354 , J:101128 )

• mice show features of malignant transformation in some of the adenomas by 10 months of age (J:65354)

• 60% of mutants develop hepatocellular carcinoma by 12 months of age (J:101128)

• tumors are predominantly well-differentiated (J:101128)

increased liver adenoma incidence ( J:65354 )

• 100% incidence of adenomas by 10-12 months of age

cellular

increased hepatocyte proliferation ( J:65354 )

• livers show an increase in cell proliferation; at one month of age, the proliferation index is increased about 1.4-fold compared to wild-type, then proliferation decreases at 2 months of age so it is 2-fold lower than at 1 months of age but it is 6-fold higher than in wild-type livers at this time

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:65354 , J:101128 , J:170790