Phenotypes Associated with This Genotype

Genotype
MGI:5437515

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺; Tg(Gfap-cre)2Brn/0
• Genetic Background: either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pituitary tumor in Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Gfap-cre)2Brn/0 mice

mortality/aging

premature death ( J:187257 )

neoplasm

increased tumor incidence ( J:187257 )

• pituitary tumors, mammary gland tumors and primitive neuroectodermal tumors

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

increased mammary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

increased mammary gland tumor incidence ( J:187257 )

integument

increased mammary gland tumor incidence ( J:187257 )