Phenotypes for Gt(ROSA)26Sor Rb1 Tg(Gfap-cre)2Brn Trp53 MGI:5437517 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0
Genetic Background	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki} mutation (0 available); any Gt(ROSA)26Sor mutation (1058 available)
Rb1^tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(Gfap-cre)2Brn mutation (1 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pituitary gland tumor incidence ( J:187257 )

increased medulloblastoma incidence ( J:187257 )

• as in Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn mice

increased carcinoma incidence ( J:187257 )

• large cell carcinoma

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

increased medulloblastoma incidence ( J:187257 )

• as in Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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