Phenotypes Associated with This Genotype

Genotype
MGI:5437646

• Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺; Tg(Alb-E2F1)8Sst/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased liver tumor incidence ( J:101128 )

• mutants develop diffuse liver dysplasia by 3 months of age

increased hepatocellular carcinoma incidence ( J:101128 )

• 22% of mutants develop hepatocellular carcinomas by 6 months of age and by 9 months of age, 100% of mutants show hepatocellular carcinomas, indicating that tumors are more severe and arise faster than in single transgenic mice

• tumors are predominantly moderately well differentiated with trabecular, solid and trabecular/pseudoglandular pattern

liver/biliary system

increased liver tumor incidence ( J:101128 )

• mutants develop diffuse liver dysplasia by 3 months of age

increased hepatocellular carcinoma incidence ( J:101128 )

• 22% of mutants develop hepatocellular carcinomas by 6 months of age and by 9 months of age, 100% of mutants show hepatocellular carcinomas, indicating that tumors are more severe and arise faster than in single transgenic mice

• tumors are predominantly moderately well differentiated with trabecular, solid and trabecular/pseudoglandular pattern

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:101128 , J:170790