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Phenotypes Associated with This Genotype
Genotype
MGI:5437646
Allelic
Composition
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(Alb-E2F1)8Sst/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtf2ird1Tg(Alb1-Myc)166.8Sst mutation (0 available); any Gtf2ird1 mutation (359 available)
Tg(Alb-E2F1)8Sst mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants develop diffuse liver dysplasia by 3 months of age
• 22% of mutants develop hepatocellular carcinomas by 6 months of age and by 9 months of age, 100% of mutants show hepatocellular carcinomas, indicating that tumors are more severe and arise faster than in single transgenic mice
• tumors are predominantly moderately well differentiated with trabecular, solid and trabecular/pseudoglandular pattern

liver/biliary system
• mutants develop diffuse liver dysplasia by 3 months of age
• 22% of mutants develop hepatocellular carcinomas by 6 months of age and by 9 months of age, 100% of mutants show hepatocellular carcinomas, indicating that tumors are more severe and arise faster than in single transgenic mice
• tumors are predominantly moderately well differentiated with trabecular, solid and trabecular/pseudoglandular pattern

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:101128 , J:170790


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory