Phenotypes Associated with This Genotype

Genotype
MGI:5437710

• Allelic Composition: X/Tg(SERPINC1-SV40)BPbr
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:84204 )

♂ • tumoral angiogenesis occurs before the development of diffuse hepatocarcinoma, with proliferation, remodeling, and arterialization of hepatic sinusoids

♂ • fused, enlarged sinusoids are present in adenomatous nodules at 16 weeks of age, and when hepatocarcinoma is seen, the architecture of the liver is disrupted with large vascular lakes replacing the sinusoids

♂ • some transformed hepatocytes exhibit an endothelial cell phenotype, suggesting a partial vasculogenic mimicry

♂ • the abnormal angiogenesis seen in hepatocarcinoma is associated with platelet aggregation within vascular endothelial cells derived form the portal tract and sinusoid lumen

increased hepatocellular carcinoma incidence ( J:84204 , J:101541 )

♂ • males exhibit hepatocyte hyperplasia/dysplasia at 4 weeks of age, show nodules corresponding to adenomas from the 12th week of age and diffuse hepatocarcinoma from the 20th week of age (J:84204)

♂ • all mice develop hepatocellular carcinoma by 8 months of age (J:101541)

increased liver adenoma incidence ( J:84204 )

♂

cardiovascular system

abnormal tumor vascularization ( J:84204 )

♂ • tumoral angiogenesis occurs before the development of diffuse hepatocarcinoma, with proliferation, remodeling, and arterialization of hepatic sinusoids

♂ • fused, enlarged sinusoids are present in adenomatous nodules at 16 weeks of age, and when hepatocarcinoma is seen, the architecture of the liver is disrupted with large vascular lakes replacing the sinusoids

♂ • some transformed hepatocytes exhibit an endothelial cell phenotype, suggesting a partial vasculogenic mimicry

♂ • the abnormal angiogenesis seen in hepatocarcinoma is associated with platelet aggregation within vascular endothelial cells derived form the portal tract and sinusoid lumen

hematopoietic system

increased macrophage cell number ( J:84204 )

♂ • macrophages invade the hepatic tissue before development of tumoral angiogenesis

immune system

increased macrophage cell number ( J:84204 )

♂ • macrophages invade the hepatic tissue before development of tumoral angiogenesis

liver/biliary system

increased hepatocellular carcinoma incidence ( J:84204 , J:101541 )

♂ • males exhibit hepatocyte hyperplasia/dysplasia at 4 weeks of age, show nodules corresponding to adenomas from the 12th week of age and diffuse hepatocarcinoma from the 20th week of age (J:84204)

♂ • all mice develop hepatocellular carcinoma by 8 months of age (J:101541)

increased liver adenoma incidence ( J:84204 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:84204 , J:101541