Phenotypes Associated with This Genotype

Genotype
MGI:5438091

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/0; Usp9x^tm1Tuv/Usp9x⁺
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186717 )

♀ • due to local or metastatic pancreatic cancer or aggressive oral papillomas

neoplasm

increased oral papilloma incidence ( J:186717 )

♀ • aggressive oral papillomas

increased pancreas tumor incidence ( J:186717 )

♀ • within 3 months, mice develop pancreatic intraepithelial neoplasia and microinvasive neoplasms

increased pancreatic intraepithelial neoplasia incidence ( J:186717 )

♀ • within 3 months

increased skin papilloma incidence ( J:186717 )

♀ • in the face and urogenital area at 3 months

integument

increased skin papilloma incidence ( J:186717 )

♀ • in the face and urogenital area at 3 months

endocrine/exocrine glands

increased pancreas tumor incidence ( J:186717 )

♀ • within 3 months, mice develop pancreatic intraepithelial neoplasia and microinvasive neoplasms

increased pancreatic intraepithelial neoplasia incidence ( J:186717 )

♀ • within 3 months

craniofacial

increased oral papilloma incidence ( J:186717 )

♀ • aggressive oral papillomas

growth/size/body

increased oral papilloma incidence ( J:186717 )

♀ • aggressive oral papillomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:186717