About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5438092
Allelic
Composition
Btbd9Gt(RRE078)Byg/Btbd9Gt(RRE078)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9Gt(RRE078)Byg mutation (0 available); any Btbd9 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• paired pulse ratios at three different inter-stimulus intervals are enhanced suggesting a defect in short term plasticity
• enhanced long term potentiation suggests a defect in long term plasticity
• suggesting a defect in long term plasticity
• decreased frequency and amplitude but no changes in rise or decay times
• paired pulse ratios at three different inter-stimulus intervals are enhanced

behavior/neurological
• travel a greater distance in an open field assay
• increase in activity when placed in constant darkness but significant alterations in circadian rhythms
• increase in counterclockwise circling but no difference in clockwise circling
• decrease in slow wave sleep and increase in awake time but no change in REM
• increase in arousals
• decrease in response time to a warm stimulus in a tail flick assay
• treatment with ropinirole rescues the sensory alteration

homeostasis/metabolism
• increase in 5-HIAA, a metabolite of serotonin, in the striatum suggesting an alteration in serotonin metabolism
• however, no alteration in serotonin levels are detected in the striatum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:187433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory