nervous system
• paired pulse ratios at three different inter-stimulus intervals are enhanced suggesting a defect in short term plasticity
• enhanced long term potentiation suggests a defect in long term plasticity
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• suggesting a defect in long term plasticity
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• decreased frequency and amplitude but no changes in rise or decay times
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• paired pulse ratios at three different inter-stimulus intervals are enhanced
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behavior/neurological
• travel a greater distance in an open field assay
• increase in activity when placed in constant darkness but significant alterations in circadian rhythms
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• increase in counterclockwise circling but no difference in clockwise circling
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• decrease in slow wave sleep and increase in awake time but no change in REM
• increase in arousals
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• decrease in response time to a warm stimulus in a tail flick assay
• treatment with ropinirole rescues the sensory alteration
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homeostasis/metabolism
• increase in 5-HIAA, a metabolite of serotonin, in the striatum suggesting an alteration in serotonin metabolism
• however, no alteration in serotonin levels are detected in the striatum
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
restless legs syndrome | DOID:0050425 |
OMIM:PS102300 |
J:187433 |