Phenotypes for Cul4b Edil3 MGI:5438241 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cul4b^tm1Swl/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	B6.Cg-Edil3^{Tg(Sox2-cre)1Amc} Cul4b^tm1Swl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1Swl mutation (0 available); any Cul4b mutation (37 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:187403 )

• PTZ-induced

abnormal dendrite morphology ( J:187403 )

• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons

abnormal dendritic spine morphology ( J:187403 )

• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons

decreased neuron number ( J:187403 )

• fewer PV+ hippocampal neurons

• however, mice exhibit normal numbers of SS+ and GAD67+ neurons

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:187403 )

• PTZ-induced

abnormal spatial learning ( J:187403 )

• impaired in a Morris water maze

impaired spatial working memory ( J:187403 )

• impaired in a Morris water maze

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
intellectual disability		DOID:1059		J:187403

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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