Phenotypes Associated with This Genotype

Genotype
MGI:5440902

• Allelic Composition: Wnt7a^px-J/Wnt7a^px-J
• Genetic Background: C57BL/6J-Wnt7a^px-J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

oligodactyly ( J:188477 )

• all have missing or shortened digits of the front paws but only a few have missing digits of the hind paws

abnormal forelimb morphology ( J:188477 )

• the front limbs are malformed and shortened

short forelimb ( J:188477 )

abnormal limb development ( J:188477 )

hemimelia ( J:188477 )

reproductive system

abnormal sperm motility ( J:188477 )

♂ • sperm appear sluggish but can be used successfully for in vitro fertilization

female infertility ( J:188477 )

♀ • although females are infertile they can be used successfully as ovarian transplant donors for reproduction

male infertility ( J:188477 )

♂

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:188477 )

N • auditory brainstem response is normal at 2 months of age

vision/eye

vision/eye phenotype ( J:188477 )

N

cellular

abnormal sperm motility ( J:188477 )

♂ • sperm appear sluggish but can be used successfully for in vitro fertilization

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fuhrmann syndrome		DOID:0090067	OMIM:228930	J:188477