About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5441312
Allelic
Composition
Tg(Vav1-JAK2*V617F)AZjz/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens weigh 2-8 times more than those of controls
• 75% of mutants exhibit a strong elevation of platelets but with normal or slightly increased counts of white blood and red blood cells, resembling essential thrombocythemia
• 25% of mutants show abnormally high levels of red blood cells and white blood cells as well as platelets, resembling polycythemia vera
• bone marrow and spleen give rise to an increase in hematopoietic colonies, indicating the presence of a larger percentage of progenitor cells
• bone marrow cells produce an increased number of granulocyte-macrophage colony-forming cell colonies compared to controls in the absence of growth factors
• mutants exhibit autonomous formation of erythrocyte colony-forming unit colonies with cells from bone marrow
• megakaryocytic hyperplasia in the spleen and bone marrow
• mutants exhibit an increase in the number of megakaryocytic progenitor cells in the bone marrow
• erythroid hyperplasia in the spleen and bone marrow
• mutants exhibit many smaller red blood cells
• mutants exhibit increased number of platelets
• occasional presence of giant platelets
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen

homeostasis/metabolism
• plasma thyroid peroxidase levels are decreased

immune system
• spleens weigh 2-8 times more than those of controls
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen

skeleton
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen

growth/size/body
• spleens weigh 2-8 times more than those of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory