hematopoietic system
• spleens weigh 2-8 times more than those of controls
|
• 75% of mutants exhibit a strong elevation of platelets but with normal or slightly increased counts of white blood and red blood cells, resembling essential thrombocythemia
• 25% of mutants show abnormally high levels of red blood cells and white blood cells as well as platelets, resembling polycythemia vera
|
• bone marrow and spleen give rise to an increase in hematopoietic colonies, indicating the presence of a larger percentage of progenitor cells
• bone marrow cells produce an increased number of granulocyte-macrophage colony-forming cell colonies compared to controls in the absence of growth factors
• mutants exhibit autonomous formation of erythrocyte colony-forming unit colonies with cells from bone marrow
|
• megakaryocytic hyperplasia in the spleen and bone marrow
|
• mutants exhibit an increase in the number of megakaryocytic progenitor cells in the bone marrow
|
• erythroid hyperplasia in the spleen and bone marrow
|
microcytosis
(
J:135993
)
• mutants exhibit many smaller red blood cells
|
• mutants exhibit increased number of platelets
|
• occasional presence of giant platelets
|
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen
|
homeostasis/metabolism
• plasma thyroid peroxidase levels are decreased
|
immune system
• spleens weigh 2-8 times more than those of controls
|
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen
|
skeleton
• 10 of 26 mutants develop various degrees of fibrosis in the bone marrow and spleen
|
growth/size/body
• spleens weigh 2-8 times more than those of controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
essential thrombocythemia | DOID:2224 |
OMIM:187950 OMIM:601977 OMIM:614521 |
J:135993 | |
myelofibrosis | DOID:4971 |
OMIM:254450 |
J:135993 | |
polycythemia vera | DOID:8997 |
OMIM:263300 |
J:135993 |