Phenotypes Associated with This Genotype

Genotype
MGI:5441339

• Allelic Composition: Hbb-b1^tm1Unc/Hbb-b1⁺; Hbb-b2^tm1Unc/Hbb-b2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:185154 )

increased erythroid progenitor cell number ( J:185154 )

• increase in the proportion of immature erythroid progenitor cells in the spleen

abnormal erythrocyte morphology ( J:185154 )

abnormal erythropoiesis ( J:185154 )

• impaired

decreased erythrocyte cell number ( J:185154 )

• in males and females compared to sex and age matched littermates at 6 months of age

decreased hemoglobin content ( J:185154 )

• in males and females compared to sex and age matched littermates at 6 months of age

decreased mean corpuscular volume ( J:185154 )

• in males and females compared to sex and age matched littermates at 6 months of age

reticulocytosis ( J:185154 )

• increase in the percentage of reticulocytes

increased spleen iron level ( J:185154 )

• more severe in females than in males

homeostasis/metabolism

increased spleen iron level ( J:185154 )

• more severe in females than in males

increased circulating erythropoietin level ( J:185154 )

• remarkably high serum levels

• levels are higher in males than in females

increased liver iron level ( J:185154 )

• more severe in females than in males

liver/biliary system

increased liver iron level ( J:185154 )

• more severe in females than in males

immune system

enlarged spleen ( J:185154 )

increased spleen iron level ( J:185154 )

• more severe in females than in males

growth/size/body

enlarged spleen ( J:185154 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:185154