Phenotypes Associated with This Genotype

Genotype
MGI:5441532

• Allelic Composition: Xbp1^tm2Glm/Xbp1^tm2Glm; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal hemorrhage ( J:188627 )

• in DSS-treated mice

abnormal small intestine goblet cell morphology ( J:188627 )

• reduced number and size in the small intestine with reduced secretory granules

absent Paneth cells ( J:188627 )

• absent with barely detectable lysozyme and pro-forms of cryptdin stores

crypts of Lieberkuhn abscesses ( J:188627 )

• in some mice

intestinal ulcer ( J:188627 )

• in some mice

abnormal intestine physiology ( J:188627 )

• mice exhibit an increase in the migration rate of proliferating cells in the crypt-villus compared with control mice

increased susceptibility to induced colitis ( J:188627 )

• mice treated with DSS exhibit more severe wasting and rectal bleeding and increased areas of mucosal erosions, edema and cellular infiltration compared with control mice

• however, antibiotic treatment rescues increased sensitivity

small intestinal inflammation ( J:188627 )

• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice

• inflammation is patchy and ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas

• however, mice do not exhibit reduced villus length

immune system

increased susceptibility to induced colitis ( J:188627 )

• mice treated with DSS exhibit more severe wasting and rectal bleeding and increased areas of mucosal erosions, edema and cellular infiltration compared with control mice

• however, antibiotic treatment rescues increased sensitivity

small intestinal inflammation ( J:188627 )

• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice

• inflammation is patchy and ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas

• however, mice do not exhibit reduced villus length

increased susceptibility to bacterial infection ( J:188627 )

• mice infected with Listeria monocytogenes exhibit increased bacterial burden in the feces and liver compared with control mice

• however, bacterial burden in the spleen is normal

cardiovascular system

rectal hemorrhage ( J:188627 )

• in DSS-treated mice

cellular

abnormal small intestine goblet cell morphology ( J:188627 )

• reduced number and size in the small intestine with reduced secretory granules

abnormal endoplasmic reticulum morphology ( J:188627 )

• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice

abnormal cell migration ( J:188627 )

• mice exhibit an increase in the migration rate of proliferating cells in the crypt-villus compared with control mice

growth/size/body

cachexia ( J:188627 )

• in DSS-treated mice

endocrine/exocrine glands

absent Paneth cells ( J:188627 )

• absent with barely detectable lysozyme and pro-forms of cryptdin stores

crypts of Lieberkuhn abscesses ( J:188627 )

• in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:188627