Phenotypes Associated with This Genotype

Genotype
MGI:5441548

• Allelic Composition: Tg(Ins2-Tag*,-flpe)#Gne/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic islet cell carcinoma incidence ( J:188693 )

• shows the same temporal progression of multistage islet cell carcinogenesis as mice carrying Tg(RIP1-Tag)2Dh

• early intervention (before 10 weeks of age) with anti-VEGF treatment results in a dramatic reduction of tumors and decreased tumor microvascular density

endocrine/exocrine glands

increased pancreatic islet cell carcinoma incidence ( J:188693 )

• shows the same temporal progression of multistage islet cell carcinogenesis as mice carrying Tg(RIP1-Tag)2Dh

• early intervention (before 10 weeks of age) with anti-VEGF treatment results in a dramatic reduction of tumors and decreased tumor microvascular density

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:188693