Phenotypes Associated with This Genotype

Genotype
MGI:5441551

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Trp53^tm1Lejo/Trp53^tm1Lejo
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187012 )

• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)

• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

neoplasm

increased lung small cell carcinoma incidence ( J:187012 )

• following infection with Ad-FIC

• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system

abnormal lung morphology ( J:187012 )

• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

increased lung small cell carcinoma incidence ( J:187012 )

• following infection with Ad-FIC

• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung small cell carcinoma		DOID:5409	OMIM:182280	J:187012