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Phenotypes Associated with This Genotype
Genotype
MGI:5441555
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm1Lejo/Trp53tm1Lejo
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Trp53tm1Lejo mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung non-small cell carcinoma incidence ( J:187012 )
• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)
increased lung adenocarcinoma incidence ( J:187012 )
• following infection with Ad-FIC

respiratory system
increased lung non-small cell carcinoma incidence ( J:187012 )
• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)
increased lung adenocarcinoma incidence ( J:187012 )
• following infection with Ad-FIC

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
 J:187012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory