Phenotypes Associated with This Genotype

Genotype
MGI:5442284

• Allelic Composition: Tg(OMP-SV40T)13Bse/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:54269 )

• some mutants die from intra-abdominal bleeding from spontaneously ruptured, highly vascularized adrenal tumors

neoplasm

increased adrenal gland tumor incidence ( J:54269 )

• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

increased metastatic potential ( J:54269 )

• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia

• metastasis into liver, lungs, and para-aortic lymph nodes

increased neuroblastoma incidence ( J:54269 )

• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia that resemble human infant neuroblastoma

• tumor incidence is 18%

• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:54269 )

• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

nervous system

increased neuroblastoma incidence ( J:54269 )

• starting from 4 months of age, mutants present with highly metastatic tumors originating in the adrenal medulla or sympathetic ganglia that resemble human infant neuroblastoma

• tumor incidence is 18%

• most tumors typically are bilateral adrenal tumors with multiple metastatic nodules in liver, lungs, and para-aortic lymph nodes

immune system

abnormal immune tolerance ( J:54269 )

• 4-week old mutants do not have measurable levels of antibodies against SV40 Tag, but by 5 months of age, they show a humoral immune response against the transgene product, indicating a lack of immunological tolerance to Tag

• adrenal glands with no evidence of tumors show lymphocytic infiltrations, signs of medullary cell destruction and hemorrhagic areas at the cortico-medullary border

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:54269