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Phenotypes Associated with This Genotype
Genotype
MGI:5442286
Allelic
Composition
Tg(rTH-Tag)20Dmc/0
Genetic
Background
involves: C57BL/6NTac * DBA/2NTac
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• adrenal glands develop tumors resembling neuroblastomas
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

nervous system
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

endocrine/exocrine glands
• adrenal glands develop tumors resembling neuroblastomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:90323


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory