About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5442747
Allelic
Composition
Ptentm1Rps/Pten+
Tg(Wnt1)1Hev/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (88 available)
Tg(Wnt1)1Hev mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin
• mutants occasionally show pulmonary metastasis
• tumors are adenocarcinomas with cribiform, cystic and focal papillary growth patterns
• 50% of males develop tumors by 5.5 months and all males develop tumors within 10 months
• 50% of females develop tumors by 3.5 months of age and all females have tumors within 5 months of age
• 6 of 22 tumors in males are bilateral or unilateral muzzle tumors of epithelial origin
• 7 or 11 tumors show loss of Pten heterozygosity
• most mutants (38 of 49) develop only one palpable tumor
• 14 of 22 tumors in males arise in the salivary tissue

endocrine/exocrine glands
• 14 of 22 tumors in males arise in the salivary tissue
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin

integument
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin

digestive/alimentary system
• 14 of 22 tumors in males arise in the salivary tissue

craniofacial
• 14 of 22 tumors in males arise in the salivary tissue

growth/size/body
• 14 of 22 tumors in males arise in the salivary tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:67497


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory