neoplasm
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin
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• mutants occasionally show pulmonary metastasis
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• tumors are adenocarcinomas with cribiform, cystic and focal papillary growth patterns
• 50% of males develop tumors by 5.5 months and all males develop tumors within 10 months
• 50% of females develop tumors by 3.5 months of age and all females have tumors within 5 months of age
• 6 of 22 tumors in males are bilateral or unilateral muzzle tumors of epithelial origin
• 7 or 11 tumors show loss of Pten heterozygosity
• most mutants (38 of 49) develop only one palpable tumor
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• 14 of 22 tumors in males arise in the salivary tissue
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endocrine/exocrine glands
• 14 of 22 tumors in males arise in the salivary tissue
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• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin
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integument
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin
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digestive/alimentary system
• 14 of 22 tumors in males arise in the salivary tissue
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craniofacial
• 14 of 22 tumors in males arise in the salivary tissue
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growth/size/body
• 14 of 22 tumors in males arise in the salivary tissue
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
breast cancer | DOID:1612 |
OMIM:114480 |
J:67497 |