Phenotypes Associated with This Genotype

Genotype
MGI:5444190

• Allelic Composition: Prss56^glcr4/Prss56^glcr4
• Genetic Background: involves: C3H/HeA * C57BL/6J * C57BL/LiA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina ganglion cell degeneration ( J:188765 )

• develop glaucomatous neurodegeneration characterized by retinal ganglion cell death following the increase in intraocular pressure

optic nerve atrophy ( J:188765 )

• develop glaucomatous neurodegeneration characterized by optic nerve atrophy following the increase in intraocular pressure

abnormal eye physiology ( J:188765 )

• aqueous humor drainage is compromised contributing to the increase in intraocular pressure

ocular hypertension ( J:188765 )

• detected in around 50% of mice at 3 months of age and around 90% of mice at 12 months of age

nervous system

retina ganglion cell degeneration ( J:188765 )

• develop glaucomatous neurodegeneration characterized by retinal ganglion cell death following the increase in intraocular pressure

optic nerve atrophy ( J:188765 )

• develop glaucomatous neurodegeneration characterized by optic nerve atrophy following the increase in intraocular pressure

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated microphthalmia 6		DOID:0060835	OMIM:613517	J:188765