vision/eye
• the angle is narrow and the iris is closely apposed to the trabecular meshwork
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• focally hypoplastic with substantially reduced collagen fibrils in the trabecular beams and an increase in open spaces lacking extracellular matrix
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• in some mice at 3 months of age
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• variable decrease (ranging from 0-10% shorter than in controls) in axial length at 2 months of age
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• in severely affected mice
• Background Sensitivity: reduction in axial length is more severe in mice on an inbred C3H/HeA background than in mice on a C57BL/6 background
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• focal regions with abnormal crowding of collagen fibrils
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• expanded and thicker by as early as 2 months of age
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• pupil dilation induces a large increase in intraocular pressure
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
isolated microphthalmia 6 | DOID:0060835 |
OMIM:613517 |
J:188765 |