Phenotypes Associated with This Genotype

Genotype
MGI:5444484

• Allelic Composition: Tgfb2^tm1Doe/Tgfb2⁺
• Genetic Background: STOCK Tgfb2^tm1Doe/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta wall morphology ( J:188799 )

• elastic fiber fragmentation and greater collagen deposition within the medial compartment of the aortic wall is increased compared to wild-type mice

dilated aorta bulb ( J:188799 )

• by 8 months of age, heterozygotes show dilation of the aortic annulus and root

• however, dimensions of the more distal ascending aorta are normal

aortic aneurysm ( J:188799 )

• aortic root aneurysm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Loeys-Dietz syndrome		DOID:0050466		J:188799