Phenotypes Associated with This Genotype

Genotype
MGI:5444705

cx3

• Allelic Composition: Fzd2^tm1.1Nat/Fzd2^tm1.1Nat; Fzd7^tm1.1Nat/Fzd7^tm1.1Nat
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:189062 )

• die around E10.5

embryo

disorganized yolk sac vascular plexus ( J:189062 )

• fail to develop an organized vascular plexus at E9.5

incomplete embryo turning ( J:189062 )

• fail to complete tail turning

embryonic growth retardation ( J:189062 )

• at E8.5

decreased embryo size ( J:189062 )

• modest decrease in size at E8.5

abnormal embryonic tissue morphology ( J:189062 )

• strikingly rotund morphology at E8.5 (length:width ratio of around 2 compared to around 3.5 in controls)

open neural tube ( J:189062 )

abnormal parietal yolk sac morphology ( J:189062 )

• at E10.5 the yolk sac vasculature is engorged with blood

cardiovascular system

decreased angiogenesis ( J:189062 )

• rudimentary vasculature at E9.5

disorganized yolk sac vascular plexus ( J:189062 )

• fail to develop an organized vascular plexus at E9.5

abnormal heart development ( J:189062 )

• fail to develop left-right heart asymmetry

nervous system

open neural tube ( J:189062 )

growth/size/body

embryonic growth retardation ( J:189062 )

• at E8.5

decreased embryo size ( J:189062 )

• modest decrease in size at E8.5