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Phenotypes Associated with This Genotype
Genotype
MGI:5444719
cx11
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=6) display cardiac defects compared to 0% of embryos heterozygous for either mutation alone
ventricular septal defect ( J:189062 )
• most defects are VSDs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory