Phenotypes Associated with This Genotype

Genotype
MGI:5445342

• Allelic Composition: Drc1^b2b1654Clo/Drc1^b2b1654Clo
• Genetic Background: C57BL/6J-Drc1^b2b1654Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1654-002-MNA displays levocardia with dual hepatic vein

cardiovascular system

abnormal aortic arch morphology ( J:175213 )

interrupted aortic arch ( J:175213 )

interrupted aortic arch, type b ( J:175213 )

abnormal azygos vein morphology ( J:175213 )

• azygous venous connection

abnormal hepatic vein morphology ( J:175213 )

• dual hepatic vein

abnormal inferior vena cava morphology ( J:175213 )

dual inferior vena cava ( J:175213 )

l-loop transposition of the great arteries ( J:175213 )

• L-loop transposition of the great arteries

atrial septal defect ( J:175213 )

dextrocardia ( J:175213 )

ventricular septal defect ( J:175213 )

growth/size/body

heterotaxia ( J:175213 )

abdominal situs ambiguus ( J:175213 )

abdominal situs inversus ( J:175213 )

left pulmonary isomerism ( J:175213 )

• Left bronchial isomerism Left bronchial isomerism Left bronchial isomerism

situs inversus totalis ( J:175213 )

situs inversus with levocardia ( J:175213 )

craniofacial

micrognathia ( J:175213 )

skeleton

micrognathia ( J:175213 )

respiratory system

left pulmonary isomerism ( J:175213 )

• Left bronchial isomerism Left bronchial isomerism Left bronchial isomerism

hematopoietic system

absent spleen ( J:175213 )

immune system

absent spleen ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia 21		DOID:0110596	OMIM:615294	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213