Phenotypes Associated with This Genotype

Genotype
MGI:5445344

• Allelic Composition: Flt3^tm1Dgg/Flt3⁺; Kmt2a^tm1Clgr/Kmt2a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:189096 )

• median survival of 49 weeks of age compared to 75-94 weeks of age for wild-type and single heterozygotes

neoplasm

increased leukemia incidence ( J:189096 )

• 100% penetrance of acute leukemia at a median age of 49 weeks

• 70% develop acute myeloid leukemia

• 12% develop unclassifiable acute leukemia

• 9% develop B-cell leukemia

• 9% develop biphenotypic leukemia

• loss of Flt3 heterozygosity is seen in leukemias

hematopoietic system

enlarged spleen ( J:189096 )

anemia ( J:189096 )

increased erythroblast number ( J:189096 )

• presence of more than or equal to 20% blasts in blood and blasts in nonhematopoietic organs, including liver and adrenal glands

thrombocytopenia ( J:189096 )

increased leukocyte cell number ( J:189096 )

• mutants develop leukocytosis

immune system

enlarged spleen ( J:189096 )

increased leukocyte cell number ( J:189096 )

• mutants develop leukocytosis

growth/size/body

enlarged spleen ( J:189096 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:189096