Phenotypes for Flt3 Kmt2a MGI:5445345 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Flt3^tm1Dgg/Flt3^tm1Dgg Kmt2a^tm1Clgr/Kmt2a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3^tm1Dgg mutation (8 available); any Flt3 mutation (90 available)
Kmt2a^tm1Clgr mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:189096 )

• median survival is 19 weeks of age

neoplasm

increased leukemia incidence ( J:189096 )

• 89% develop acute myeloid leukemia

• 11% develop B-cell leukemia

• disease is more aggressive than in double heterozygous mutants

hematopoietic system

enlarged spleen ( J:189096 )

increased leukocyte cell number ( J:189096 )

immune system

enlarged spleen ( J:189096 )

increased leukocyte cell number ( J:189096 )

growth/size/body

enlarged spleen ( J:189096 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:189096

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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