mortality/aging
• median survival is 19 weeks of age
|
neoplasm
• 89% develop acute myeloid leukemia
• 11% develop B-cell leukemia
• disease is more aggressive than in double heterozygous mutants
|
hematopoietic system
immune system
growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
acute myeloid leukemia | DOID:9119 |
OMIM:601626 |
J:189096 |