Phenotypes for Flt3 Kmt2a MGI:5445345 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Flt3^tm1Dgg/Flt3^tm1Dgg Kmt2a^tm1Clgr/Kmt2a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3^tm1Dgg mutation (8 available); any Flt3 mutation (90 available)
Kmt2a^tm1Clgr mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:189096 )

• median survival is 19 weeks of age

neoplasm

increased leukemia incidence ( J:189096 )

• 89% develop acute myeloid leukemia

• 11% develop B-cell leukemia

• disease is more aggressive than in double heterozygous mutants

hematopoietic system

enlarged spleen ( J:189096 )

increased leukocyte cell number ( J:189096 )

immune system

enlarged spleen ( J:189096 )

increased leukocyte cell number ( J:189096 )

growth/size/body

enlarged spleen ( J:189096 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:189096

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24