Phenotypes Associated with This Genotype

Genotype
MGI:5445935

• Allelic Composition: Scn5a^{tm3(SCN5A*)Rdn}/Scn5a^{tm3(SCN5A*)Rdn}
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart ventricle ( J:189389 )

dilated heart left ventricle ( J:189389 )

dilated cardiomyopathy ( J:189389 )

decreased cardiac muscle contractility ( J:189389 )

decreased heart rate ( J:189389 )

• at 3 and 12 weeks, progressive with age

ventricular tachycardia ( J:189389 )

• spontaneous monomorphic and polymorphic ventricular tachycardia in 7 of 9 mice at 12 weeks

atrial fibrillation ( J:189389 )

• in 5 mice

atrioventricular block ( J:189389 )

• in 4 mice

prolonged PR interval ( J:189389 )

• at 3 and 12 weeks, progressive with age

abnormal heart electrocardiography waveform feature ( J:189389 )

• at 3 and 12 weeks, progressive with age

prolonged QRS complex duration ( J:189389 )

• at 3 and 12 weeks, progressive with age

abnormal sinoatrial node conduction ( J:189389 )

• in 3 mice

prolonged P wave ( J:189389 )

• at 3 and 12 weeks, progressive with age

abnormal myocardial fiber physiology ( J:189389 )

• myocytes exhibit decreased action potential amplitude, decreased peak sodium current and prolonged action potential duration compared with cells from wild-type mice

muscle

dilated cardiomyopathy ( J:189389 )

decreased cardiac muscle contractility ( J:189389 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1E		DOID:0110433	OMIM:601154	J:189389