Phenotypes Associated with This Genotype

Genotype
MGI:5446426

• Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo
• Genetic Background: C57BL/6J-Dnah11^b2b1775Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1775-005-LA displays dextrocardia, inverted lung lobe, malrotation of intestines

cardiovascular system

abnormal inferior vena cava morphology ( J:175213 )

• absence of the suprarenal inferior vena cava with azygous continuation

dual inferior vena cava ( J:175213 )

double outlet right ventricle ( J:175213 )

dextrocardia ( J:175213 )

ventricular septal defect ( J:175213 )

digestive/alimentary system

abnormal intestine morphology ( J:175213 )

• gut malrotation

growth/size/body

heterotaxia ( J:175213 )

abdominal situs ambiguus ( J:175213 )

abdominal situs inversus ( J:175213 )

situs inversus totalis ( J:175213 )

hematopoietic system

spleen hypoplasia ( J:175213 )

immune system

spleen hypoplasia ( J:175213 )

liver/biliary system

abnormal biliary tract morphology ( J:175213 )

• possible biliary obstruction

respiratory system

abnormal respiratory motile cilium physiology ( J:175213 )

cellular

abnormal respiratory motile cilium physiology ( J:175213 )

skeleton

abnormal vertebral column morphology ( J:175213 )

• malaligned sternal vertebra

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 7		DOID:0110605	OMIM:611884	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213