Phenotypes for Agtpbp1 MGI:5446655 MGI Mouse

decreased amacrine cell number ( J:189268 )

• reduction in the number of calbindin+ amacrine cells at P270, but not earlier time points

abnormal retina rod cell morphology ( J:189268 )

• rod bipolar cells show a progressive loss of dendrites that is first observed at P90 and is complete by P270

retina photoreceptor degeneration ( J:189268 )

• progressive loss of photoreceptor rows is evident by P90, however the outer nuclear layer is not completely lost and at P270, 2-3 rows of photoreceptor cells are retained

abnormal retina inner plexiform layer morphology ( J:189268 )

• smaller terminal end-bulbs and varicosities in the sublamine 5 of the inner plexiform layer are seen from P90

• end-bulbs of axonal terminals are disorganized and smaller

abnormal retina outer nuclear layer morphology ( J:189268 )

• in the oldest mutants (P180 and P270) some horizontal cell somas are abnormally located in the outer nuclear layer

thin retina outer nuclear layer ( J:189268 )

• progressive reduction in thickness due to photoreceptor death

abnormal eye electrophysiology ( J:189268 )

• magnitude of age-related ERG amplitude reduction is more pronounced in mutants than in wild-type mice, especially at later ages

• ERG amplitudes evoked by high intensity stimuli presented to the dark-adapted eye are smaller than in wild-type at all ages tested for the a-wave and at all ages except P45 for the b-wave

• oscillatory potential amplitudes in response to a light flash are different from wild-type

abnormal cone electrophysiology ( J:189268 )

• amplitudes of the cone ERG b-wave is decreased in mutants at P90 and older

• however, no differences from wild-type in cone flicker ERGs are seen

abnormal rod electrophysiology ( J:189268 )

• amplitude of the rod b-wave is reduced in mutants for all postnatal days measured after P90