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Phenotypes Associated with This Genotype
Genotype
MGI:5446903
Allelic
Composition
Smurf2Gt(RRA098)Byg/Smurf2Gt(RRA098)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smurf2Gt(RRA098)Byg mutation (0 available); any Smurf2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop tumors within 20 months
• lymphomas often spread to the spleen, kidney and liver
• mice begin to develop diffuse large B-cell lymphoma starting at 15 months of age, with variation in formation from 15 to 20 months (J:245679)
• a circulating microRNA signature predicts the development of lymphoma (J:245679)

digestive/alimentary system

cellular
• in mouse embryonic fibroblasts under a 3T9 protocol
• in the spleen of premalignant aged mice

liver/biliary system

hematopoietic system

immune system

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
diffuse large B-cell lymphoma DOID:0050745 J:245679


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory