Phenotypes Associated with This Genotype

Genotype
MGI:5447049

• Allelic Composition: Tg(BCL2/IGH)#Jcre/0; Tg(H2-K/Igh-Traf2*)#Ywc/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94116 )

• some mice die by 6 months

• by 14 months, less than 20% of mice are alive

immune system

decreased B cell apoptosis ( J:94116 )

• resistant to spontaneous and drug-induced apoptosis

enlarged spleen ( J:94116 )

• detected at birth

• severe at death

increased spleen weight ( J:94116 )

• 2-fold at 10 to 16 months

• 10 times at death

increased B cell number ( J:94116 )

• in the blood of mice that develop leukemia

increased B-1a cell number ( J:94116 )

• in three-quarters of mice in nodal and extranodal location

increased B-1b cell number ( J:94116 )

• in one-quarter of mice in nodal and extranodal location

abnormal spleen marginal zone morphology ( J:94116 )

• expanded due to infiltration of small B lymphocytes

increased marginal zone B cell number ( J:94116 )

• small B lymphocytes infiltrate the marginal zone

enlarged lymph nodes ( J:94116 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:94116 )

increased small lymphocytic lymphoma incidence ( J:94116 )

• small B cell lymphoma with expansion of different clones

respiratory system

pleural effusion ( J:94116 )

• common

homeostasis/metabolism

ascites ( J:94116 )

• in half of mice

pleural effusion ( J:94116 )

• common

cellular

decreased B cell apoptosis ( J:94116 )

• resistant to spontaneous and drug-induced apoptosis

hematopoietic system

decreased B cell apoptosis ( J:94116 )

• resistant to spontaneous and drug-induced apoptosis

enlarged spleen ( J:94116 )

• detected at birth

• severe at death

increased spleen weight ( J:94116 )

• 2-fold at 10 to 16 months

• 10 times at death

increased B cell number ( J:94116 )

• in the blood of mice that develop leukemia

increased B-1a cell number ( J:94116 )

• in three-quarters of mice in nodal and extranodal location

increased B-1b cell number ( J:94116 )

• in one-quarter of mice in nodal and extranodal location

abnormal spleen marginal zone morphology ( J:94116 )

• expanded due to infiltration of small B lymphocytes

increased marginal zone B cell number ( J:94116 )

• small B lymphocytes infiltrate the marginal zone

growth/size/body

enlarged spleen ( J:94116 )

• detected at birth

• severe at death

increased spleen weight ( J:94116 )

• 2-fold at 10 to 16 months

• 10 times at death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:94116