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Phenotypes Associated with This Genotype
Genotype
MGI:5448415
Allelic
Composition
Slc6a8tm1.1Clar/Y
Tg(Camk2a-cre)2Gsc/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a8tm1.1Clar mutation (1 available); any Slc6a8 mutation (10 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal motor function on a rotarod, hanging wire test and beam walk
• in the Morris water, mice exhibit impaired performance compared with control mice
• however, treatment with cyclocreatine improves performance
• in the radial arm mazes, mice exhibit impaired performance compared with control mice
• in the radial arm mazes, mice exhibit impaired performance compared with control mice
• impaired novel object recognition
• however, treatment with cyclocreatine improves performance
• during the dark phase

homeostasis/metabolism
• in the brain

adipose tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral creatine deficiency syndrome 1 DOID:0050800 OMIM:300352
J:190081


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory