Phenotypes Associated with This Genotype

Genotype
MGI:5448548

• Allelic Composition: Tg(SOD1*G85R)#Roos/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147156 )

• mean survival is 349 days

behavior/neurological

hindlimb paralysis ( J:147156 )

• progressive paralysis

growth/size/body

weight loss ( J:147156 )

• weight loss begins at 307 days of age

nervous system

astrocytosis ( J:147156 )

• in the anterior horn of the spinal cord at 350 days of age

abnormal motor neuron morphology ( J:147156 )

• SOD1-immunoreactive aggregates (of mutant SOD1 homodimers) are seen in motor neuron cells in the anterior horn at 350 days of age

motor neuron degeneration ( J:147156 )

• loss of motor neurons at 350 days of age but not at 150 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:147156