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Phenotypes Associated with This Genotype
Genotype
MGI:5451018
cn3
Allelic
Composition		 Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (90 available)
Abcg1tm1Tall mutation (1 available); any Abcg1 mutation (46 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:190966 )
• mice exhibit an increase in colony-forming units in the blood

immune system
increased interleukin-23 secretion ( J:190966 )
• 1.8-fold in the spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory