Phenotypes Associated with This Genotype

Genotype
MGI:5461066

• Allelic Composition: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}/Epm2a⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR/cd * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112696 )

• maximum survival is 9 months

• median survival is 6 months

neoplasm

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

cellular

abnormal DNA methylation ( J:112696 )

• hypermethylation of the endogenous promoter near transgene insertion

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

hematopoietic system

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

immune system

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:112696