Phenotypes Associated with This Genotype

Genotype
MGI:5461654

• Allelic Composition: Ube3a^tm1Alb/Ube3a⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal adrenaline level ( J:190050 )

• mice with maternal deficiency (inheriting the null allele from the mother) exhibit increased epinephrine levels in the midbrain

increased dopamine level ( J:190050 )

• mice with maternal deficiency exhibit increased dopamine levels in the striatum and cortex

• DOPAC levels are increased in the striatum and midbrain

increased serotonin level ( J:190050 )

• mice with maternal deficiency exhibit increased 5HT (serotonin) levels in the frontal cortex and striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Angelman syndrome		DOID:1932	OMIM:105830	J:190050